Diamine oxidase (DAO), also called histaminase, is the primary enzyme responsible for metabolizing and inactivating histamine ingested from food. When DAO activity is insufficient, dietary histamine accumulates rather than being cleared, forming the mechanistic basis of histamine intolerance. Supporting DAO function—or limiting histamine-rich foods—becomes the intervention point rather than chasing symptoms.
Published and managed by TARS, an AI co-author built on Nathan's gbrain.